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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC1
All Species:
18.48
Human Site:
S374
Identified Species:
50.83
UniProt:
Q92574
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92574
NP_000359.1
1164
129767
S374
P
D
L
S
H
P
Y
S
K
V
F
G
T
T
A
Chimpanzee
Pan troglodytes
XP_520334
1163
129674
S374
P
D
L
S
H
P
Y
S
K
V
F
G
T
T
G
Rhesus Macaque
Macaca mulatta
XP_001103589
1163
129467
S374
P
D
L
S
H
P
Y
S
K
V
F
G
T
T
G
Dog
Lupus familis
XP_537808
1169
129668
S374
P
D
L
S
H
P
Y
S
K
V
F
G
T
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9EP53
1161
128727
S370
G
N
V
P
A
D
L
S
H
P
Y
S
K
A
F
Rat
Rattus norvegicus
Q9Z136
1163
129004
S374
A
D
L
S
H
P
Y
S
K
A
F
G
T
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415449
1156
128927
Q374
E
S
S
Q
S
T
S
Q
P
Y
S
K
A
F
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001119992
1001
113305
T297
R
E
E
V
F
R
T
T
N
S
R
S
T
P
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190249
1454
159903
M388
P
P
S
P
G
G
S
M
M
D
L
S
L
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.1
89.3
N.A.
87.2
86.4
N.A.
N.A.
76.3
N.A.
N.A.
N.A.
N.A.
23.5
N.A.
25.9
Protein Similarity:
100
99.6
98.7
93.5
N.A.
92
91.4
N.A.
N.A.
84.7
N.A.
N.A.
N.A.
N.A.
43.2
N.A.
43.3
P-Site Identity:
100
93.3
93.3
93.3
N.A.
6.6
80
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
13.3
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
26.6
80
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
12
0
0
0
0
12
0
0
12
23
23
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
56
0
0
0
12
0
0
0
12
0
0
0
0
0
% D
% Glu:
12
12
12
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
12
0
0
0
0
0
56
0
0
12
12
% F
% Gly:
12
0
0
0
12
12
0
0
0
0
0
56
0
0
34
% G
% His:
0
0
0
0
56
0
0
0
12
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
56
0
0
12
12
0
0
% K
% Leu:
0
0
56
0
0
0
12
0
0
0
12
0
12
0
0
% L
% Met:
0
0
0
0
0
0
0
12
12
0
0
0
0
0
0
% M
% Asn:
0
12
0
0
0
0
0
0
12
0
0
0
0
0
0
% N
% Pro:
56
12
0
23
0
56
0
0
12
12
0
0
0
12
12
% P
% Gln:
0
0
0
12
0
0
0
12
0
0
0
0
0
0
0
% Q
% Arg:
12
0
0
0
0
12
0
0
0
0
12
0
0
0
0
% R
% Ser:
0
12
23
56
12
0
23
67
0
12
12
34
0
0
12
% S
% Thr:
0
0
0
0
0
12
12
12
0
0
0
0
67
56
12
% T
% Val:
0
0
12
12
0
0
0
0
0
45
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
56
0
0
12
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _